一种从蒙古黄芪根中提取的、对网状内皮系统有活性的酸性多糖。

An acidic polysaccharide having activity on the reticuloendothelial system from the root of Astragalus mongholicus.

作者信息

Shimizu N, Tomoda M, Kanari M, Gonda R

机构信息

Kyoritsu College of Pharmacy, Tokyo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Nov;39(11):2969-72. doi: 10.1248/cpb.39.2969.

DOI:10.1248/cpb.39.2969

PMID:1799943

Abstract

An acidic polysaccharide, designated as AMon-S, was isolated from the roots of Astragalus mongholicus BUNGE. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 7.6 x 10(4). It showed significant reticuloendothelial system-potentiating activity in a carbon clearance test. It is composed of L-arabinose: D-galactose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 18:18:1:1, in addition to small amounts of O-acetyl groups and peptide moiety. A part of the hexuronic acid residues exist as the methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies enabled elucidation of its structural features and revealed mainly alpha-arabino-beta-3,6-galactan type structural units.

摘要

从蒙古黄芪（Astragalus mongholicus BUNGE）根部分离出一种酸性多糖，命名为AMon-S。它在电泳和凝胶色谱上呈现均一性，其分子量估计为7.6×10⁴。在碳清除试验中，它表现出显著的增强网状内皮系统的活性。它由L-阿拉伯糖、D-半乳糖、D-半乳糖醛酸、D-葡萄糖醛酸以18:18:1:1的摩尔比组成，此外还含有少量的O-乙酰基和肽部分。部分己糖醛酸残基以甲酯形式存在。甲基化分析、碳-13核磁共振和高碘酸盐氧化研究有助于阐明其结构特征，并揭示其主要为α-阿拉伯糖基-β-3,6-半乳聚糖型结构单元。