Shimizu N, Tomoda M, Satoh M, Gonda R, Ohara N
Kyoritsu College of Pharmacy, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1991 Aug;39(8):2082-6. doi: 10.1248/cpb.39.2082.
An acidic polysaccharide, named glycyrrhizan GA, was isolated from the stolon of Glycyrrhiza glabra L. var. glandulifera Reg. et Herd. It produced a single band on electrophoresis and a single peak on gel chromatography, and its molecular mass was estimated to be 85,000. Glycyrrhizan GA is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 22:10:1:2:1, in addition to small amounts of O-acetyl groups. Part of the hexuronic acid residues exist as methyl esters. Methylation analysis, carbon-13 nuclear magnetic resonance and periodate oxidation studies indicated that its structural features include mainly alpha-arabino-beta-3,6-galactan type structural units. Glycyrrhizan GA showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.
从光果甘草变种腺毛甘草的匍匐茎中分离出一种名为甘草聚糖GA的酸性多糖。它在电泳中呈现单一条带，在凝胶色谱中呈现单一峰，其分子量估计为85,000。甘草聚糖GA由L-阿拉伯糖、D-半乳糖、L-鼠李糖、D-半乳糖醛酸、D-葡萄糖醛酸按22:10:1:2:1的摩尔比组成，此外还含有少量的O-乙酰基。部分己糖醛酸残基以甲酯形式存在。甲基化分析、碳-13核磁共振和高碘酸盐氧化研究表明，其结构特征主要包括α-阿拉伯糖-β-3,6-半乳聚糖型结构单元。在碳清除试验中，甘草聚糖GA表现出显著的网状内皮系统增强活性。
