Katz Alan, Katz Anne, Burchill Charles
408-727 McDermot Ave, Winnipeg, MB.
Can Fam Physician. 2007 Nov;53(11):1936-42.
To explore the extent to which biochemical testing is used to diagnose androgen deficiency before initiating treatment and to learn whether recommendations for clinical monitoring of men taking androgen therapy are being followed.
Population-based retrospective cohort study.
Winnipeg, Man.
A total of 902 men who filled at least 2 prescriptions for androgen therapy.
Whether men had had baseline prostate-specific antigen (PSA) and testosterone testing before initiation of therapy and whether men had been monitored during the first year of treatment.
Of the 902 men who filled first-time prescriptions during the study period, only 475 (52.7%) had ever had PSA or testosterone tests. Before starting therapy, 315 men (34.9%) had had PSA tests, and 152 men (16.9%) had had testosterone tests. Less than 1% of the entire sample had had 3 or more tests during the year following initiation of therapy.
Indications for androgen therapy in this population appear to be based on clinical symptoms rather than on demonstrated biochemical androgen deficiency. Recommendations for clinical monitoring of men taking androgen therapy are not followed consistently.
探讨在开始治疗前使用生化检测诊断雄激素缺乏的程度，并了解服用雄激素疗法的男性临床监测建议是否得到遵循。
基于人群的回顾性队列研究。
加拿大马尼托巴省温尼伯市。
共有902名男性至少开具过2次雄激素治疗处方。
男性在开始治疗前是否进行过基线前列腺特异性抗原（PSA）和睾酮检测，以及男性在治疗的第一年是否接受过监测。
在研究期间首次开具处方的902名男性中，只有475名（52.7%）曾进行过PSA或睾酮检测。在开始治疗前，315名男性（34.9%）进行过PSA检测，152名男性（16.9%）进行过睾酮检测。在开始治疗后的一年内，整个样本中不到1%的人进行过3次或更多次检测。
该人群中雄激素治疗的指征似乎基于临床症状而非已证实的生化雄激素缺乏。服用雄激素疗法的男性临床监测建议未得到一致遵循。
