由连接基促进的固相烯烃交叉复分解反应

Solid-phase olefin cross-metathesis promoted by a linker.

作者信息

Garner Amanda L, Koide Kazunori

机构信息

Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.

出版信息

Org Lett. 2007 Dec 6;9(25):5235-8. doi: 10.1021/ol702415x. Epub 2007 Nov 15.

DOI:10.1021/ol702415x

PMID:18001044

Abstract

Olefin cross-metathesis couples two alkenes to form complex molecules and has been widely used in solution-phase organic synthesis. However, this powerful method has rarely been used in solid-phase organic synthesis. Herein we report that olefin cross-metathesis is a synthetically viable method particularly when a traceless longer linker is inserted between solid support and reacting olefins.

摘要

烯烃复分解反应将两个烯烃偶联形成复杂分子，已广泛应用于溶液相有机合成中。然而，这种强大的方法在固相有机合成中很少被使用。在此我们报道，烯烃复分解反应是一种具有合成可行性的方法，尤其是当在固相载体和反应烯烃之间插入无痕长连接基时。