Gunesh S, Thomas G A O, Williams G T, Roberts A, Hawthorne A B
Department of Gastroenterology, University Hospital of Wales, Cardiff, UK.
Aliment Pharmacol Ther. 2008 Feb 1;27(3):211-9. doi: 10.1111/j.1365-2036.2007.03576.x. Epub 2007 Nov 14.
The incidence of Crohn's disease rose rapidly in industralized countries over the past 50 years, but it is unclear whether the incidence is still rising or has reached a plateau.
To update the long-term incidence study of Crohn's disease in Cardiff for 1996-2005, to investigate whether incidence is still rising and to study changes in disease characteristics over time.
Crohn's cases identified by retrospective analysis of hospital records as in previous studies in Cardiff.
Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 x 10(6) per year (95% confidence interval: 58-76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in those with terminal ileal disease. There remains a strong female preponderance (F:M 1.6:1) as in previous studies. The incidence in children under age 16 continues to rise, and the median age at diagnosis has fallen slightly.
Crohn's disease incidence continues to rise slowly in Cardiff with a continuing increase in those presenting with colonic disease, which is now the commonest disease pattern.
在过去50年中，克罗恩病在工业化国家的发病率迅速上升，但目前尚不清楚发病率是否仍在上升或已达到平台期。
更新1996 - 2005年加的夫克罗恩病的长期发病率研究，调查发病率是否仍在上升，并研究疾病特征随时间的变化。
与加的夫之前的研究一样，通过对医院记录的回顾性分析来确定克罗恩病病例。
共确定了212例病例。这十年的校正发病率为每年66×10⁻⁶（95%置信区间：58 - 76），与之前几十年相比呈持续上升趋势。初诊时结肠疾病患者的比例持续上升（43%），同时末端回肠疾病患者的比例相应下降。与之前的研究一样，女性优势仍然明显（女：男为1.6：1）。16岁以下儿童的发病率持续上升，诊断时的中位年龄略有下降。
在加的夫，克罗恩病发病率继续缓慢上升，结肠疾病患者数量持续增加，目前结肠疾病是最常见的疾病类型。
