Williams Paul
Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
Cell Host Microbe. 2007 Jun 14;1(4):248-9. doi: 10.1016/j.chom.2007.05.010.
How probiotics such as Bacillus subtilis exert a protective effect has been much debated. In this issue of Cell Host & Microbe, Fujiya et al. reveal that a B. subtilis quorum-sensing signal molecule, the competence- and sporulation-stimulating factor (CSF), is internalized via the mammalian oligopeptide transporter OCTN2, where it induces the heat shock protein Hsp27, which protects intestinal cells against oxidant-mediated tissue damage and loss of barrier function.
诸如枯草芽孢杆菌之类的益生菌如何发挥保护作用一直备受争议。在本期的《细胞宿主与微生物》杂志中，藤屋等人揭示，一种枯草芽孢杆菌群体感应信号分子，即感受态和芽孢形成刺激因子（CSF），经由哺乳动物寡肽转运体OCTN2内化，在那里它诱导热休克蛋白Hsp27，后者可保护肠道细胞免受氧化介导的组织损伤和屏障功能丧失的影响。
