Abou-Shady E A, Farrag H E, el-Damarawy N A, Mohamed F A, Kamel A M, Massoud A A
Department of Physiology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Egypt Public Health Assoc. 1991;66(1-2):1-20.
The present study portrays the effects of some elements, namely: iron, zinc, copper, magnesium and gold, on platelet count, PCV and platelet aggregation, 60 minutes following administration of the metal salts. Marked thrombocytopenia was encountered in rats treated with ferrous sulphate while the platelet count was significantly changed with the other elements tested. The PCV was significantly increased following treatment with ferrous sulphate and large dose of gold chloride, but was insignificantly altered with the other elements. As regards platelet aggregation, all metals tested, with the exception of magnesium caused significant inhibition of platelet aggregation was only significantly impaired following treatment with iron and gold, but was insignificantly altered following treatment with zinc and copper. On the other hand, treatment with magnesium resulted in enhancement of both ADP- and collagen-induced aggregation. The mechanisms underlying these effects are discussed.
本研究描述了某些元素，即铁、锌、铜、镁和金，在给予金属盐60分钟后对血小板计数、红细胞压积和血小板聚集的影响。用硫酸亚铁治疗的大鼠出现明显的血小板减少，而血小板计数在测试的其他元素作用下有显著变化。用硫酸亚铁和大剂量氯化金治疗后红细胞压积显著增加，但在其他元素作用下变化不明显。关于血小板聚集，除镁外，所有测试金属均引起血小板聚集的显著抑制，仅在铁和金治疗后血小板聚集显著受损，而在锌和铜治疗后变化不明显。另一方面，镁治疗导致ADP和胶原诱导的聚集均增强。讨论了这些作用的潜在机制。
