Talhouk Rabih S, Zeinieh Michele P, Mikati Mohamad A, El-Sabban Marwan E
Department of Biology, American University of Beirut, Beirut, Lebanon.
Prog Neurobiol. 2008 Jan;84(1):57-76. doi: 10.1016/j.pneurobio.2007.10.001. Epub 2007 Oct 10.
Brain hypoxia-ischemia is a relatively common and serious problem in neonates and in adults. Its consequences include long-term histological and behavioral changes and reduction in seizure threshold. Gap junction intercellular communication is pivotal in the spread of hypoxia-ischemia related injury and in mediating its long-term effects. This review provides a comprehensive and critical review of hypoxia-ischemia and hypoxia in the brain and the potential role of gap junctions in the spread of the neuronal injury induced by these insults. It also presents the effects of hypoxia-ischemia and of hypoxia on the state of gap junctions in vitro and in vivo. Understanding the mechanisms involved in gap junction-mediated neuronal injury due to hypoxia will lead to the development of novel therapeutic strategies.
脑缺氧缺血在新生儿和成人中是一个相对常见且严重的问题。其后果包括长期的组织学和行为改变以及癫痫阈值降低。缝隙连接细胞间通讯在缺氧缺血相关损伤的传播及其长期影响的介导中起关键作用。本综述全面且批判性地回顾了脑内的缺氧缺血和缺氧情况，以及缝隙连接在这些损伤所致神经元损伤传播中的潜在作用。它还介绍了缺氧缺血和缺氧对体外和体内缝隙连接状态的影响。了解缺氧导致缝隙连接介导的神经元损伤所涉及的机制将有助于开发新的治疗策略。
