患痴呆症风险较高的唐氏综合征患者的神经影像学：可能存在代偿性事件的证据。
Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events.
作者信息
Haier R J, Head K, Head E, Lott I T
机构信息
Department of Pediatrics, University of California, Irvine 92697-4475, USA.
出版信息
Neuroimage. 2008 Feb 1;39(3):1324-32. doi: 10.1016/j.neuroimage.2007.09.064. Epub 2007 Oct 12.
BACKGROUND
We report functional and structural brain indicators that may precede the onset of dementia in individuals with Down's syndrome (DS).
METHODS
Middle-aged adults with DS (n=19), a group known to be at high risk for dementia, were studied with (1) positron emission tomography (PET) to determine cerebral glucose metabolic rate (GMR), (2) structural magnetic resonance imaging (MRI) to determine gray matter volume (GM), and (3) ratings of potential dementia indicators based on a structured interview of caregiver observations designed to evaluate individuals with low intelligence.
RESULTS
Although none of the participants showed clinical signs of dementia, ratings of dementia indicators were correlated to both functional and structural imaging. The strongest correlations (p<.05, corrected for multiple comparisons) included the combination of higher GMR and decreased GM volume in parts of the temporal cortex, including the parahippocampus/hippocampus, in the thalamus, caudate, and frontal lobe (BA 47).
INTERPRETATION
The combination of increased GMR overlapping with less gray matter in these areas may be consistent with a compensatory brain response to an early stage of the disease process.
背景
我们报告了可能先于唐氏综合征（DS）患者痴呆症发作的大脑功能和结构指标。
方法
对19名中年DS成年人进行了研究，这组人已知患痴呆症风险很高，研究内容包括：（1）正电子发射断层扫描（PET）以确定脑葡萄糖代谢率（GMR）；（2）结构磁共振成像（MRI）以确定灰质体积（GM）；（3）基于对照顾者观察结果的结构化访谈对潜在痴呆指标进行评分，该访谈旨在评估智力低下个体。
结果
尽管没有参与者表现出痴呆的临床症状，但痴呆指标评分与功能和结构成像均相关。最强的相关性（p<0.05，经多重比较校正）包括颞叶部分（包括海马旁回/海马）、丘脑、尾状核和额叶（BA 47）中较高的GMR与减少的GM体积的组合。
解读
这些区域中GMR增加与灰质减少的组合可能与疾病过程早期大脑的代偿反应一致。
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