Zammit Matthew D, Laymon Charles M, Tudorascu Dana L, Hartley Sigan L, Piro-Gambetti Brianna, Johnson Sterling C, Stone Charles K, Mathis Chester A, Zaman Shahid H, Klunk William E, Handen Benjamin L, Cohen Ann D, Christian Bradley T
University of Wisconsin-Madison Waisman Center Madison Wisconsin USA.
Department of Radiology, University of Pittsburgh Pittsburgh Pennsylvania USA.
Alzheimers Dement (Amst). 2021 Jan 13;12(1):e12138. doi: 10.1002/dad2.12138. eCollection 2020.
Adults with Down syndrome (DS) are predisposed to Alzheimer's disease (AD) and the relationship between cognition and glucose metabolism in this population has yet to be evaluated.
Adults with DS (N = 90; mean age [standard deviation] = 38.0 [8.30] years) underwent [C-11]Pittsburgh compound B (PiB) and [F-18]fluorodeoxyglucose (FDG) positron emission tomography scans. Associations among amyloid beta (Aβ), FDG, and measures of cognition were explored. Interregional FDG metabolic connectivity was assessed to compare cognitively stable DS and mild cognitive impairment/AD (MCI-DS/AD).
Negative associations between Aβ and FDG were evident in regions affected in sporadic AD. A positive association was observed in the putamen, which is the brain region showing the earliest increases in Aβ deposition. Both Aβ and FDG were associated with measures of cognition, and metabolic connectivity distinguished cases of MCI-DS/AD from cognitively stable DS.
Associations among Aβ, FDG, and cognition reveal that neurodegeneration in DS resembles sporadic AD with the exception of the putamen, highlighting the usefulness of FDG in monitoring neurodegeneration in DS.
唐氏综合征（DS）成人易患阿尔茨海默病（AD），而该人群认知与葡萄糖代谢之间的关系尚未得到评估。
90名DS成人（平均年龄[标准差]=38.0[8.30]岁）接受了[C-11]匹兹堡化合物B（PiB）和[F-18]氟脱氧葡萄糖（FDG）正电子发射断层扫描。探讨了淀粉样β蛋白（Aβ）、FDG与认知指标之间的关联。评估了区域间FDG代谢连通性，以比较认知稳定的DS和轻度认知障碍/AD（MCI-DS/AD）。
在散发性AD受累区域，Aβ与FDG之间存在明显的负相关。在壳核中观察到正相关，壳核是Aβ沉积最早增加的脑区。Aβ和FDG均与认知指标相关，代谢连通性可将MCI-DS/AD病例与认知稳定的DS区分开来。
Aβ、FDG与认知之间的关联表明，除壳核外，DS中的神经退行性变与散发性AD相似，这突出了FDG在监测DS神经退行性变中的作用。
