身体约束对白细胞介素-1β和脂多糖诱导发热的影响。

The effect of physical restraint on IL-1 beta- and LPS-induced fever.

作者信息

Long N C, Morimoto A, Nakamori T, Murakami N

机构信息

Department of Physiology, Yamaguchi University Medical School, Ube, Japan.

出版信息

Physiol Behav. 1991 Sep;50(3):625-8. doi: 10.1016/0031-9384(91)90556-4.

DOI:10.1016/0031-9384(91)90556-4

PMID:1801019

Abstract

The stress of physical restraint has been shown to cause an elevation in the body temperature of rats. In this study, we compared the febrile responses of restrained and unrestrained animals to the injection of interleukin-1 beta (IL-1 beta) and lipopolysaccharide (LPS). We found that, prior to injection, the body temperature of the restrained animals was about 1 degree C higher than that of the unrestrained rats. The restrained rats showed significantly smaller increases in body temperature in response to the injection of either pyrogen than did the unrestrained animals.

摘要

已表明身体受到束缚的压力会导致大鼠体温升高。在本研究中，我们比较了受束缚和未受束缚的动物在注射白细胞介素 -1β（IL-1β）和脂多糖（LPS）后的发热反应。我们发现，在注射前，受束缚动物的体温比未受束缚的大鼠高约1摄氏度。与未受束缚的动物相比，受束缚的大鼠在注射任何一种致热原后体温升高幅度明显较小。