Kuhner M K, Lawlor D A, Ennis P D, Parham P
Department of Integrative Biology, University of California, Berkeley.
Tissue Antigens. 1991 Oct;38(4):152-64. doi: 10.1111/j.1399-0039.1991.tb01889.x.
Sixty-five DNA sequences from human and chimpanzee major histocompatibility complex class I loci were searched for statistical evidence of past gene conversion. Twenty-four potential conversions were detected; they were distributed across both variable and conserved portions of the gene, and involved both classical and non-classical loci. The majority spanned less than 100 bp, comparable in length to the conversions observed in spontaneous mutations in mice. Both within-locus and between-locus conversions were observed. Certain areas of the antigen recognition site appear to have been the target for multiple conversion events. The implications of these findings for the evolution of the class I multigene family are discussed.
对来自人类和黑猩猩主要组织相容性复合体I类基因座的65个DNA序列进行搜索，以寻找过去基因转换的统计证据。检测到24个潜在的转换；它们分布在基因的可变部分和保守部分，并且涉及经典和非经典基因座。大多数转换跨度小于100 bp，长度与在小鼠自发突变中观察到的转换相当。观察到了基因座内和基因座间的转换。抗原识别位点的某些区域似乎是多次转换事件的目标。讨论了这些发现对I类多基因家族进化的影响。
