Lawlor D A, Warren E, Taylor P, Parham P
Department of Cell Biology, Stanford University School of Medicine, California 94305.
J Exp Med. 1991 Dec 1;174(6):1491-509. doi: 10.1084/jem.174.6.1491.
14 gorilla class I major histocompatibility complex (MHC) alleles have been isolated, sequenced, and compared to their counterparts in humans and chimpanzees. Gorilla homologues of HLA-A, -B, and -C were readily identified, and four Gogo-A, four Gogo-B, and five Gogo-C alleles were defined. In addition, an unusual Gogo class I gene with features in common with HLA-A and its related pseudogene, HLA-H, is described. None of the gorilla alleles is identical or even closely related to known class I alleles and each encodes a unique antigen recognition site. However, the majority of polymorphic substitutions and sequence motifs of gorilla class I alleles are shared with the human or chimpanzee systems. In particular, elements shared with HLA-A2 and HLA-B27 are found in Gogo-A and -B alleles. Diversity at the Gogo-B locus is less than at the Gogo-A locus, a trend the opposite of that seen for HLA-A and -B. The Gogo-C locus also appears to have limited polymorphism compared to Gogo-A. Two basic Gogo-C motifs were found and they segregate with distinctive sets of HLA-C alleles. HLA-A allels are divided into five families derived from two ancient lineages. All chimpanzee A alleles derived from one of these lineages and all gorilla alleles derive from the other. Unlike chimpanzee Patr-A alleles, the Gogo-A alleles do not clearly partition with one of the HLA-A families but have similarities with two. Overall, gorilla class I diversity appears from this sampling to show more distinctions from class I HLA than found for chimpanzee class I.
14个大猩猩I类主要组织相容性复合体（MHC）等位基因已被分离、测序，并与人类和黑猩猩的对应等位基因进行了比较。很容易鉴定出HLA - A、- B和- C的大猩猩同源物，并确定了4个Gogo - A、4个Gogo - B和5个Gogo - C等位基因。此外，还描述了一个不寻常的Gogo I类基因，它具有与HLA - A及其相关假基因HLA - H共同的特征。没有一个大猩猩等位基因与已知的I类等位基因相同甚至密切相关，并且每个等位基因都编码一个独特的抗原识别位点。然而，大猩猩I类等位基因的大多数多态性替换和序列基序与人类或黑猩猩系统共享。特别是，在Gogo - A和- B等位基因中发现了与HLA - A2和HLA - B27共享的元件。Gogo - B位点的多样性低于Gogo - A位点，这一趋势与HLA - A和- B相反。与Gogo - A相比，Gogo - C位点似乎也具有有限的多态性。发现了两个基本的Gogo - C基序，它们与不同的HLA - C等位基因组分离。HLA - A等位基因分为五个源自两个古老谱系的家族。所有黑猩猩A等位基因都源自这些谱系之一，而所有大猩猩等位基因都源自另一个谱系。与黑猩猩Patr - A等位基因不同，Gogo - A等位基因没有明显地与HLA - A家族之一划分在一起，而是与两个家族都有相似之处。总体而言，从这个样本来看，大猩猩I类多样性与I类HLA的差异似乎比黑猩猩I类更多。
