Lienert K, Parham P
Department of Structural Biology, Stanford University School of Medicine, CA 94305-5400, USA.
Immunol Cell Biol. 1996 Aug;74(4):349-56. doi: 10.1038/icb.1996.62.
The classical major histocompatibility complex (MHC) class I genes are conserved in higher primates. Motifs common to human, chimpanzee and gorilla alleles indicate that class I alleles diverged from ancestral sequences that existed before separation of these species. Analysis of native human populations such as Australian Aborigines and Amerindians shows that HLA-B is characterized by rapid generation of new alleles. HLA-A and -C appear to be evolving more slowly. Comparison of alleles for orthologous class I genes in humans and other primates confirms that similar mechanisms contribute to the generation of new alleles in these species.
经典的主要组织相容性复合体（MHC）I类基因在高等灵长类动物中是保守的。人类、黑猩猩和大猩猩等位基因共有的基序表明，I类等位基因与这些物种分离之前存在的祖先序列有所不同。对澳大利亚原住民和美洲印第安人等本地人群的分析表明，HLA - B的特征是新等位基因的快速产生。HLA - A和 - C的进化似乎较为缓慢。人类和其他灵长类动物直系同源I类基因等位基因的比较证实，类似的机制促成了这些物种中新等位基因的产生。
