Myrup B
Ugeskr Laeger. 1991 Oct 21;153(43):2996-8.
In five meticulously controlled investigations, the question of whether deep thrombophlebitis and pulmonary embolism may be signs of occult cancer was raised. One investigation was considered to be of doubtful value on account of selection. In two other investigations, an increased risk for cases of cancer was found among patients under the age of 50 years in whom suspicion of thrombophlebitis was confirmed and among patients with verified suspicion of pulmonary embolism. Two investigations reveal that the risk of cancer is particularly great if no risk factor for deep thrombophlebitis (so-called idiopathic deep thrombophlebitis) was found. In one of these investigations, problems concerning blinding were, however, present and the possible solution is not commented upon. On the present basis, arguments exist for a paraclinical investigation of patients with idiopathic deep thrombophlebitis or with pulmonary embolism. Investigation is probably only necessary in other patients with deep thrombophlebitis if symptoms suggestive of cancer are present and patients under the age of 50 years should be offered outpatient control in view of the possibility of cancer.
在五项精心控制的调查中，提出了深部血栓性静脉炎和肺栓塞是否可能是隐匿性癌症迹象的问题。由于选择问题，一项调查被认为价值存疑。在另外两项调查中，在50岁以下确诊为血栓性静脉炎的患者以及确诊怀疑有肺栓塞的患者中，发现患癌症的风险增加。两项调查显示，如果未发现深部血栓性静脉炎的危险因素（所谓的特发性深部血栓性静脉炎），患癌症的风险尤其高。然而，在其中一项调查中，存在盲法相关问题，且未对可能的解决方案进行评论。基于目前的情况，有理由对特发性深部血栓性静脉炎或肺栓塞患者进行临床辅助检查。对于其他深部血栓性静脉炎患者，可能仅在出现提示癌症的症状时才需要进行检查，鉴于患癌症的可能性，50岁以下的患者应接受门诊检查。
