Khomenko I S, Chukanov V I, Gergert V Ia, Utkin V V
Probl Tuberk. 1990(1):24-8.
One hundred forty eight patients with common forms of pulmonary tuberculosis in an outbreak phase and the presence of secondary immunodeficiency were observed. Caverns were found in 80.4% and bacterial excretion, in 87.16% of the cases. Group 1 (71 persons) received chemotherapeutic drugs only; group 2 (21 persons), chemotherapeutic drugs and T-activin; group 3 (33 persons), chemotherapeutic drugs and corticosteroids; and group 4 (23 persons), chemotherapeutic drugs, corticosteroids and T-activin. The bacterial excretion in all the groups was found to be the same. The regression of infiltrative changes in the lungs by the 6-th month of treatment was more significantly registered in the groups of patients on a regimen containing chemotherapeutic drugs, corticosteroids and T-activin. Cavern closure rate appeared to be the lowest in subjects receiving chemotherapeutic drugs and corticosteroids; the addition of T-activin increases the cavern closure index. The combination of chemotherapeutic drugs, corticosteroids and T-activin promotes the normalization of the cellular immunity and increases the efficacy of pulmonary tuberculosis treatment.
观察了148例处于暴发期且存在继发性免疫缺陷的常见类型肺结核患者。80.4%的病例发现有空洞，87.16%的病例有细菌排泄。第1组（71人）仅接受化疗药物；第2组（21人）接受化疗药物和T-激活素；第3组（33人）接受化疗药物和皮质类固醇；第4组（23人）接受化疗药物、皮质类固醇和T-激活素。发现所有组的细菌排泄情况相同。在接受含化疗药物、皮质类固醇和T-激活素方案治疗的患者组中，治疗第6个月时肺部浸润性改变的消退更为明显地显现出来。接受化疗药物和皮质类固醇治疗的患者空洞闭合率似乎最低；添加T-激活素可提高空洞闭合指数。化疗药物、皮质类固醇和T-激活素的联合使用可促进细胞免疫正常化并提高肺结核治疗效果。
