Kaplan N M
University of Texas Southwestern Medical Center, Dallas 75235-8899.
Cardiovasc Drugs Ther. 1991 Dec;5(6):973-8. doi: 10.1007/BF00143522.
In the past, therapy of hypertension has not provided protection against coronary heart disease. The possible reasons are multiple and likely will never be fully ascertained. Nonetheless, numerous changes in therapy can be made that should reduce coronary risk. These include more careful monitoring of the blood pressure with particular care for control of high levels during the early morning hours; attention to all alterable risk factors with care to avoid worsening of other risks with antihypertensive drugs; adroit use of nondrug therapies; and, when drugs are used, the pressure should be lowered slowly and only to a level that avoids coronary hypoperfusion.
过去，高血压治疗未能预防冠心病。可能的原因是多方面的，而且可能永远无法完全确定。尽管如此，仍可进行多种治疗调整，以降低冠心病风险。这些调整包括更密切地监测血压，尤其要注意控制清晨时段的高血压；关注所有可改变的危险因素，注意避免使用抗高血压药物时使其他风险恶化；巧妙运用非药物治疗；并且，在使用药物时，血压应缓慢降低，且仅降至避免冠状动脉灌注不足的水平。
