Department of Gastroenetrology and Hepatology, Koshigaya Hospital, Dokkyo Medical University, Saitama, Japan.
Hepatol Res. 2008 Apr;38(4):335-9. doi: 10.1111/j.1872-034X.2007.00275.x. Epub 2007 Nov 16.
Reflux esophagitis is becoming increasingly more prevalent in Japan. It has been noted that symptomatic gastroesophageal reflux disease (GERD) and chronic liver disease may adversely affect patients' quality of life.
In the present study, 238 chronic liver disease patients (151 patients with chronic hepatitis and 87 patients with liver cirrhosis) were enrolled. The diagnosis of GERD was made based on the Quality-of-Life and Utility Evaluation Survey Technology questionnaire. Health-related quality of life was evaluated using the Short Forum 36 questionnaire.
Symptomatic GERD was present in 31.8% (48/151) of patients with chronic hepatitis and 36.8% (32/87) of patients with liver cirrhosis. Among the chronic hepatitis group, compared to the GERD-negative group, the GERD-positive group had significantly lower scores in six domains, including "rolelimitation due to physical problem", "bodily pain", "general health perception", "vitality", "role limitation due to emotional problem", and "mental health". Among the cirrhotic group, compared to the GERD-negative group, the GERD-positive group had significantly lower scores in the "role limitation due to emotional problem" domain. Significant improvement in the "physical functioning", "bodily pain", and "general health perception" domain scores was noted in chronic hepatitis patients treated with rabeprazole.
The QOL of chronic liver disease patients with symptomatic GERD was impaired.
反流性食管炎在日本越来越普遍。有研究表明，有症状的胃食管反流病（GERD）和慢性肝病可能会对患者的生活质量产生不利影响。
本研究共纳入 238 例慢性肝病患者（慢性肝炎 151 例，肝硬化 87 例）。根据生活质量和效用评估调查技术问卷诊断 GERD。采用简短量表 36 问卷评估健康相关生活质量。
在慢性肝炎患者中，有症状的 GERD 发生率为 31.8%（48/151），在肝硬化患者中为 36.8%（32/87）。在慢性肝炎组中，与 GERD 阴性组相比，GERD 阳性组在 6 个领域的评分明显较低，包括“因身体问题导致的角色受限”、“身体疼痛”、“一般健康感知”、“活力”、“因情绪问题导致的角色受限”和“心理健康”。在肝硬化组中，与 GERD 阴性组相比，GERD 阳性组在“因情绪问题导致的角色受限”领域的评分明显较低。在接受雷贝拉唑治疗的慢性肝炎患者中，“身体机能”、“身体疼痛”和“一般健康感知”领域的评分显著改善。
有症状的 GERD 会损害慢性肝病患者的生活质量。
