Burstein D
Department of Radiology, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
J Magn Reson Imaging. 1991 May-Jun;1(3):337-46. doi: 10.1002/jmri.1880010312.
Methods for imaging flow in coronary arteries with magnetic resonance (MR) imaging techniques are demonstrated in isolated heart preparations and live animal models. Coronary artery flow was first imaged with a flow-compensated gradient-echo pulse sequence in isovolumic and working perfused rat hearts and then in vivo. A bolus tracking technique was used to measure flow velocity in the coronary arteries. Ultrafast gradient-echo imaging techniques were then applied, with high resolution obtained by combining the information from several cardiac cycles. A stimulated-echo pulse sequence was demonstrated as a method for performing coronary angiography by flow tagging in isovolumic perfused hearts. This report describes the results of coronary flow MR imaging in isolated rat hearts and live mice and rats. The general approach has proved useful in evaluating new methods for coronary MR angiography and should permit well-controlled studies of pathologic conditions. This ability to image coronary flow in isolated hearts and in small animals should permit integrated MR studies of coronary flow, myocardial perfusion, myocardial metabolism, and cellular ionic status.
利用磁共振（MR）成像技术对冠状动脉血流进行成像的方法在离体心脏标本和活体动物模型中得到了验证。首先，在等容和工作灌注的大鼠心脏中，然后在活体中，使用流动补偿梯度回波脉冲序列对冠状动脉血流进行成像。采用团注追踪技术测量冠状动脉中的血流速度。随后应用超快速梯度回波成像技术，通过合并来自多个心动周期的信息获得高分辨率图像。在等容灌注心脏中，一种受激回波脉冲序列被证明是通过血流标记进行冠状动脉造影的一种方法。本报告描述了在离体大鼠心脏以及活体小鼠和大鼠中进行冠状动脉血流MR成像的结果。这一通用方法已被证明有助于评估冠状动脉MR血管造影的新方法，并且应该能够对病理状况进行严格控制的研究。这种在离体心脏和小动物中对冠状动脉血流进行成像的能力，应该能够实现对冠状动脉血流、心肌灌注、心肌代谢和细胞离子状态的综合MR研究。
