Pietrzak Aldona T, Zalewska Anna, Chodorowska Grazyna, Krasowska Dorota, Michalak-Stoma Anna, Nockowski Piotr, Osemlak Paweł, Paszkowski Tomasz, Roliński Jacek M
Chair and Department of Dermatology, Medical University of Lublin, Poland.
Clin Chim Acta. 2008 Aug;394(1-2):7-21. doi: 10.1016/j.cca.2008.04.005. Epub 2008 Apr 12.
Psoriasis is a chronic autoimmune hyperproliferative skin disease of varying severity affecting approximately 2-3% of the general population in the USA and Europe. Although the pathogenesis of psoriasis has not been fully elucidated, an immunologic-genetic relationship is likely. Cutaneous and systemic overexpression of various proinflammatory cytokines (TNF, interleukins, interferon-gamma) has been demonstrated in psoriatic patients.
We reviewed the current database literature and summarized the involvement of cytokines and their receptors in the pathogenesis and treatment of psoriasis.
Although many cytokine/anti-cytokine therapies have been conducted, TNF antagonists in the treatment of both psoriasis arthropatica and vulgaris appear to be the most widely used clinically. Interestingly, the efficacy and tolerability of some cytokines (rhIL-11 or ABX-IL-8,) were found to be much lower than expected.
Preliminary results obtained with cytokine and anti-cytokine therapies appear promising and as such continued research is clearly indicated.
银屑病是一种慢性自身免疫性增殖性皮肤病，病情严重程度各异，在美国和欧洲约影响2% - 3%的普通人群。尽管银屑病的发病机制尚未完全阐明，但免疫 - 遗传关系可能存在。银屑病患者已证实存在多种促炎细胞因子（肿瘤坏死因子、白细胞介素、干扰素 - γ）的皮肤和全身过表达。
我们回顾了当前的数据库文献，并总结了细胞因子及其受体在银屑病发病机制和治疗中的作用。
尽管已经进行了许多细胞因子/抗细胞因子治疗，但肿瘤坏死因子拮抗剂在治疗关节病型和寻常型银屑病方面似乎是临床上应用最广泛的。有趣的是，发现某些细胞因子（重组人白细胞介素 - 11或ABX - 白细胞介素 - 8）的疗效和耐受性远低于预期。
细胞因子和抗细胞因子治疗获得的初步结果似乎很有前景，因此显然需要继续进行研究。
