一氧化碳可能减轻缺血再灌注损伤：一例来自一氧化碳中毒供体的复杂肾移植病例报告

Carbon monoxide may reduce ischemia reperfusion injury: a case report of complicated kidney transplantation from a carbon monoxide poisoned donor.

作者信息

Bojakowski K, Gaciong Z, Grochowiecki T, Szmidt J

机构信息

Department of General, Vascular and Transplant Surgery, Warsaw Medical University, Warsaw, Poland.

出版信息

Transplant Proc. 2007 Nov;39(9):2928-9. doi: 10.1016/j.transproceed.2007.08.063.

DOI:10.1016/j.transproceed.2007.08.063

PMID:18022019

Abstract

Carbon monoxide (CO), well known from clinical observation to be a deadly poisoning gas, in many animal experiments has revealed a beneficial effect to diminish ischemia/reperfusion injury and rejection of transplanted organs. Data on clinical transplantation of organs retrieved from poisoned persons are limited and discordant; some authors were reported good results, whereas others described high complication rates including death. We herein have described a case of organ transplantation retrieved from a CO-poisoned donor. Warm ischemia during the transplantation procedure was prolonged to 100 minutes, but no complications were observed in the posttransplant course. This report may represent CO preconditioning in clinical transplantation.

摘要

一氧化碳（CO），从临床观察中众所周知它是一种致命的中毒气体，但在许多动物实验中显示出对减轻缺血/再灌注损伤以及移植器官排斥反应具有有益作用。关于从中毒者获取的器官进行临床移植的数据有限且不一致；有报道称一些作者取得了良好的结果，而另一些人则描述了包括死亡在内的高并发症发生率。我们在此描述了一例从一氧化碳中毒供体获取的器官移植病例。移植过程中的热缺血时间延长至100分钟，但在移植后过程中未观察到并发症。本报告可能代表了临床移植中的一氧化碳预处理。