Wang Wei-sheng, Long Zi-jiang, Zhang Ling, Bian Hai, Wang Liang, Chen Ming
Anhui College of Traditional Chinese Medicine, Hefei 230038, China.
Zhongguo Zhong Yao Za Zhi. 2007 Aug;32(16):1703-5.
To observe the effects of sapindoside on blood pressure, Ang II, Ald, ET in the blood plasma and NO in the serum in renovascular hypertension rat.
The 2K1C (2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 5 weeks. The blood pressure was measured at the 1, 3, 7, 14, 21, 28, 35 day after drug. At the end of 5th weeks, the Ang II, Ald, ET in the blood plasma and NO in the serum were measured.
Sapindoside (H, M and L) by ig. for 5 weeks could significantly lower the blood pressure, increase the levels of NO in the serum, reduce the concentration of Ang II, Ald, ET in the blood plasma.
Sapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.
观察无患子皂苷对肾血管性高血压大鼠血压、血浆血管紧张素Ⅱ（AngⅡ）、醛固酮（Ald）、内皮素（ET）及血清一氧化氮（NO）的影响。
采用两肾一夹（2K1C）高血压模型大鼠，灌胃给药5周。于给药后第1、3、7、14、21、28、35天测量血压。在第5周结束时，检测血浆中AngⅡ、Ald、ET及血清中NO的含量。
灌胃给予无患子皂苷（高、中、低剂量）5周可显著降低血压，提高血清中NO水平，降低血浆中AngⅡ、Ald、ET浓度。
无患子皂苷在降低肾血管性高血压大鼠血压方面发挥重要作用。
