对需要胸腺嘧啶的大肠杆菌菌株抑制子表型的修饰。

Modification of the suppressor phenotype of thymine requiring strains of Escherichia coli.

作者信息

Herrington M B, Basso J, Faraci M, Autexier C

机构信息

Biology Department, Concordia University, Montreal, Quebec, Canada.

出版信息

Genet Res. 1991 Dec;58(3):185-92. doi: 10.1017/s0016672300029931.

DOI:10.1017/s0016672300029931

Abstract

Thymine requiring strains of Escherichia coli suppress nonsense and frameshift mutations during translation. Strains with different genetic backgrounds exhibited different nonsense suppression spectra and showed differences in the apparent suppression efficiency. Part of this strain difference is due to a presumably novel gene (tsmA) mapping near 39 min. This gene affects the spectrum and apparent efficiency of suppression, and appears to affect the utilization of thymidine.

摘要

需要胸腺嘧啶的大肠杆菌菌株在翻译过程中抑制无义突变和移码突变。具有不同遗传背景的菌株表现出不同的无义抑制谱，并且在表观抑制效率上存在差异。这种菌株差异的部分原因是一个可能位于39分钟附近的新基因（tsmA）。该基因影响抑制的谱和表观效率，并且似乎影响胸腺嘧啶核苷的利用。

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Nonsense suppression in thymine-requiring strains of Escherichia coli is a consequence of altered folate metabolism.在需要胸腺嘧啶的大肠杆菌菌株中，无义抑制是叶酸代谢改变的结果。

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