Motika Meike S, Zhang Jun, Cashman John R
Human Biomolecular Research Institute, 5310 Eastgate Mall, San Diego, CA 92121, USA.
Expert Opin Drug Metab Toxicol. 2007 Dec;3(6):831-45. doi: 10.1517/17425255.3.6.831.
This review summarizes information concerning the association of the human flavin-containing monooxygenase 3 (FMO3) and human diseases. Human FMO3 oxygenates a wide variety of nucleophilic heteroatom-containing xenobiotics, including endogenous substrates and various clinically important drugs. In this article, the authors discuss the association of FMO3 with human disease, including: i) direct association of FMO3 genetic mutations to human genetic disease; ii) association of FMO3 genetic polymorphism to altered drug metabolism and, therefore, indirect association of FMO3 with drug therapeutic efficacy of human disease; and iii) the potential impact and/or effect of FMO3 transcriptional regulation during disease states. Even though many studies discussed for the latter two points are at a preliminary stage and require much more research to bring to a definite conclusion, the authors include these studies to stimulate general interest and invite further discussion.
本综述总结了有关人类含黄素单加氧酶3（FMO3）与人类疾病关联的信息。人类FMO3可氧化多种含亲核杂原子的外源性物质，包括内源性底物和各种临床上重要的药物。在本文中，作者讨论了FMO3与人类疾病的关联，包括：i）FMO3基因突变与人类遗传疾病的直接关联；ii）FMO3基因多态性与药物代谢改变的关联，以及因此FMO3与人类疾病药物治疗效果的间接关联；iii）疾病状态下FMO3转录调控的潜在影响和/或作用。尽管针对后两点所讨论的许多研究尚处于初步阶段，需要更多研究才能得出明确结论，但作者纳入这些研究以激发广泛兴趣并引发进一步讨论。
