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Flavin monooxygenase metabolism: why medicinal chemists should matter.黄素单加氧酶代谢：为什么药物化学家应该重视。
J Med Chem. 2014 Jul 24;57(14):6183-96. doi: 10.1021/jm5007098. Epub 2014 Jul 15.
2
Reactions and enzymes in the metabolism of drugs and other xenobiotics.药物和其他外源生物代谢中的反应和酶。
Drug Discov Today. 2012 Jun;17(11-12):549-60. doi: 10.1016/j.drudis.2012.01.017. Epub 2012 Jan 28.
3
Flavin-containing monooxygenase 3 and human disease.含黄素单加氧酶3与人类疾病
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Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase.新型Src激酶抑制剂[7-(2,6-二氯苯基)-5-甲基-苯并[1,2,4]三嗪-3-基]-[4-(2-吡咯烷-1-基乙氧基)-苯基]-胺(TG100435)及其N-氧化物代谢物通过含黄素单加氧酶和细胞色素P450还原酶的循环转化
Drug Metab Dispos. 2007 Dec;35(12):2242-51. doi: 10.1124/dmd.107.017384. Epub 2007 Sep 19.
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Insulin in flavin-containing monooxygenase regulation. Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.胰岛素在含黄素单加氧酶调节中的作用。实验性糖尿病中含黄素单加氧酶和细胞色素P450的活性
Eur J Pharm Sci. 2006 May;28(1-2):51-8. doi: 10.1016/j.ejps.2005.12.011. Epub 2006 Feb 20.
6
Human flavin-containing monooxygenases.人类含黄素单加氧酶
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Quantitative analysis of FMO gene mRNA levels in human tissues.人体组织中FMO基因mRNA水平的定量分析。
Drug Metab Dispos. 2006 Jan;34(1):19-26. doi: 10.1124/dmd.105.006171. Epub 2005 Sep 23.
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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.哺乳动物含黄素单加氧酶：结构/功能、基因多态性及其在药物代谢中的作用。
Pharmacol Ther. 2005 Jun;106(3):357-87. doi: 10.1016/j.pharmthera.2005.01.001.
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Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants.新型含黄素单加氧酶3（FMO3）单核苷酸多态性的发现及上游单倍型变体的功能分析。
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Clin Cancer Res. 2004 Dec 15;10(24):8357-62. doi: 10.1158/1078-0432.CCR-04-1073.

含黄素单加氧酶与外源化合物代谢

Flavin Containing Monooxygenases and Metabolism of Xenobiotics.

作者信息

Başaran Rahman, Can Eke Benay

机构信息

Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, Ankara, Turkey.

出版信息

Turk J Pharm Sci. 2017 Apr;14(1):90-94. doi: 10.4274/tjps.30592. Epub 2017 Apr 15.

DOI:10.4274/tjps.30592
PMID:32454599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7227999/
Abstract

This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future.

摘要

本综述总结了有关含黄素单加氧酶（FMOs）的药理学和毒理学意义的最新信息。FMOs是一族微粒体酶，参与某些异生素和含有亲核杂原子的药物的氧化反应。FMOs在药物代谢中的活性及其与疾病的关系是需要进一步探索的研究领域。未来对FMOs的研究可能会提供有关疾病病理生理学的大量信息，而与该酶家族相关的信息可能对未来的药物设计很重要。