含黄素单加氧酶与外源化合物代谢
Flavin Containing Monooxygenases and Metabolism of Xenobiotics.
作者信息
Başaran Rahman, Can Eke Benay
机构信息
Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutical Toxicology, Ankara, Turkey.
出版信息
Turk J Pharm Sci. 2017 Apr;14(1):90-94. doi: 10.4274/tjps.30592. Epub 2017 Apr 15.
Abstract
This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future.
摘要
本综述总结了有关含黄素单加氧酶（FMOs）的药理学和毒理学意义的最新信息。FMOs是一族微粒体酶，参与某些异生素和含有亲核杂原子的药物的氧化反应。FMOs在药物代谢中的活性及其与疾病的关系是需要进一步探索的研究领域。未来对FMOs的研究可能会提供有关疾病病理生理学的大量信息，而与该酶家族相关的信息可能对未来的药物设计很重要。
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