Obrenovich Mark, Siddiqui Bushra, McCloskey Benjamin, Reddy V Prakash
Research Service, Louis Stokes Cleveland, Department of Veteran's Affairs Medical Center, Cleveland, OH 44106 USA.
Department of Chemistry, Case Western Reserve University, Cleveland, OH 44115 USA.
Microorganisms. 2020 Mar 30;8(4):490. doi: 10.3390/microorganisms8040490.
It has been well established that a vegetarian and polyphenol-rich diet, including fruits, vegetables, teas, juices, wine, indigestible fiber and whole grains, provide health-promoting phytochemicals and phytonutrients that are beneficial for the heart and brain. What is not well-characterized is the affect these foods have when co-metabolized within our dynamic gut and its colonizing flora. The concept of a heart shunt within the microbiota-gut-brain axis underscores the close association between brain and heart health and the so-called "French paradox" offers clues for understanding neurodegenerative and cerebrovascular diseases. Moreover, oxidation-redox reactions and redox properties of so-called brain and heart-protective foods are underappreciated as to their enhanced or deleterious mechanisms of action. Focusing on prodromal stages, and common mechanisms underlying heart, cerebrovascular and neurodegenerative diseases, we may unmask and understanding the means to better treat these related diseases.
众所周知，素食和富含多酚的饮食，包括水果、蔬菜、茶、果汁、葡萄酒、不可消化纤维和全谷物，能提供对心脏和大脑有益的促进健康的植物化学物质和植物营养素。但这些食物在我们动态的肠道及其定植菌群中共同代谢时所产生的影响尚未得到充分表征。微生物群-肠道-大脑轴中心脏分流的概念强调了大脑和心脏健康之间的密切联系，而所谓的“法国悖论”为理解神经退行性疾病和脑血管疾病提供了线索。此外，所谓的对大脑和心脏有保护作用的食物的氧化-氧化还原反应和氧化还原特性，在其增强或有害的作用机制方面未得到充分认识。关注前驱阶段以及心脏、脑血管和神经退行性疾病的共同潜在机制，我们或许能够揭示并理解更好治疗这些相关疾病的方法。
