Nasseri-Moghaddam Siavosh, Razjouyan Hadi, Alimohamadi Seyed Maysam, Mamarabadi Mansoureh, Ghotbi Mohamad-Hamed, Mostajabi Pardis, Sohrabpour Amir-Ali, Sotoudeh Masoud, Abedi Behnoush, Mofid Azadeh, Nouraie Mehdi, Tofangchiha Shahnaz, Malekzadeh Reza
Digestive Disease Research Center (DDRC), Shariati Hospital, Medical Sciences/University of Tehran, North Kargar Ave., Tehran, Iran.
BMC Gastroenterol. 2007 Nov 20;7:42. doi: 10.1186/1471-230X-7-42.
Gastroesophageal reflux disease is a common and chronic disorder but long term, prospective studies of the fate of patients seeking medical advice are scarce. This is especially prominent when looking at non-erosive reflux disease (NERD) patients.
We designed a prospective cohort to assess the long term outcome of GERD patients referring to gastroenterologists. Consecutive consenting patients, 15 years of age and older, presenting with symptoms suggestive of GERD referring to our outpatient clinics undergo a 30 minute interview. Upper gastrointestinal endoscopy is performed for them with protocol biopsies and blood samples are drawn. Patients are then treated according to a set protocol and followed regularly either in person or by telephone for at least 10 years.
Our data show that such a study is feasible and follow-ups, which are the main concern, can be done in a fairly reliable way to collect data. The results of this study will help to clarify the course of various subgroups of GERD patients after coming to medical attention and their response to treatment considering different variables. In addition, the basic symptoms and biological database will fuel further molecular epidemiologic studies.
胃食管反流病是一种常见的慢性疾病，但对于寻求医疗建议的患者的长期前瞻性研究却很少。在观察非糜烂性反流病（NERD）患者时，这一点尤为突出。
我们设计了一个前瞻性队列研究，以评估转诊至胃肠病学家处的胃食管反流病患者的长期预后。连续同意参与研究的15岁及以上出现胃食管反流病症状并转诊至我们门诊的患者接受30分钟的访谈。为他们进行上消化道内镜检查并按方案进行活检，同时采集血样。然后根据既定方案对患者进行治疗，并亲自或通过电话定期随访至少10年。
我们的数据表明，这样的研究是可行的，而作为主要关注点的随访，可以以相当可靠的方式进行以收集数据。本研究结果将有助于阐明胃食管反流病患者在就医后各亚组的病程以及他们在考虑不同变量时对治疗的反应。此外，基本症状和生物学数据库将推动进一步的分子流行病学研究。
