Barre Annick, Sordet Camille, Culerrier Raphaël, Rancé Fabienne, Didier Alain, Rougé Pierre
Surfaces Cellulaires et Signalisation chez les Végétaux, UMR-CNRS 5546, Pôle de Biotechnologie végétale, 24 Chemin de Borde Rouge, 31326 Castanet-Tolosan, France.
Mol Immunol. 2008 Mar;45(5):1231-40. doi: 10.1016/j.molimm.2007.09.014. Epub 2007 Oct 29.
Surface-exposed IgE-binding epitopes of close overall conformation were characterized on the molecular surface of three-dimensional models built for the vicilin allergens of peanut (Ara h 1), walnut (Jug r 2), hazelnut (Cor a 11) and cashew nut (Ana o 1). They correspond to linear stretches of conserved amino acid sequences mainly located along the C-terminus of the polypeptide chains. A glyco-epitope corresponding to an exposed N-glycosylation site could also interfere with the IgE-binding epitopes. All these epitopic regions should participate in the IgE-binding cross-reactivity commonly reported between tree nuts or between peanut and some tree nuts in sensitized individuals. Owing to this epitopic community which constitutes a risk of cross-sensitization, the avoidance or a restricted consumption of other tree nuts should be recommended to peanut-sensitized individuals.
在为花生（Ara h 1）、核桃（Jug r 2）、榛子（Cor a 11）和腰果（Ana o 1）的豌豆球蛋白过敏原构建的三维模型的分子表面上，对具有紧密整体构象的表面暴露IgE结合表位进行了表征。它们对应于主要位于多肽链C末端的保守氨基酸序列的线性片段。对应于暴露的N-糖基化位点的糖表位也可能干扰IgE结合表位。所有这些表位区域都应参与致敏个体中常见的坚果之间或花生与某些坚果之间的IgE结合交叉反应。由于这种构成交叉致敏风险的表位群落，建议花生致敏个体避免食用或限制食用其他坚果。
