Boscolo-Rizzo Paolo, Maronato Francesca, Marchiori Carlo, Gava Alessandro, Da Mosto Maria Cristina
ENT Department and Regional Center for Head and Neck Cancer, University of Padua, School of Medicine, Treviso Regional Hospital, Treviso, Italy.
Laryngoscope. 2008 Feb;118(2):300-6. doi: 10.1097/MLG.0b013e31815a9ed3.
To compare the quality of life (QoL) of patients who underwent total laryngectomy with voice prosthesis insertion and postoperative radiotherapy (PORT) with those receiving concurrent chemoradiation for laryngeal preservation.
Retrospective, cross-sectional study in a tertiary academic center.
The European Organization for Research and Treatment of Cancer Quality of Life Questionnaires were used to assess long-term QoL in 67 patients treated for laryngeal cancer.
The scores of functional scales for physical (P < .000), social (P = .001), and role functioning (P = .043) were more favorable in the chemoradiation group. The global QoL score was higher in the nonsurgical group (P = .016). Surgical patients reported on sleep disturbance (P < .000), dyspnea (P = .001), and pain (P = .003), with a higher scores and greater difficulties with the senses (P < .000), social contact (P = .002) and speech (P = .010). The chemoradiation group reported greater problems with dry mouth (P < .000) and sticky saliva (P = .005).
We found better long-term QoL scores in patients undergoing concurrent chemoradiation. This appears to be mainly because of better physical functioning, social functioning, and social contact and smaller problems with pain, respiration, speech, the senses, and sleep disturbances.
比较接受全喉切除并植入发音假体及术后放疗（PORT）的患者与接受同步放化疗以保留喉功能的患者的生活质量（QoL）。
在一家三级学术中心进行的回顾性横断面研究。
使用欧洲癌症研究与治疗组织生活质量问卷评估67例喉癌患者的长期生活质量。
同步放化疗组在身体功能（P <.000）、社会功能（P =.001）和角色功能（P =.043）功能量表上的得分更优。非手术组的总体生活质量得分更高（P =.016）。手术患者报告存在睡眠障碍（P <.000）、呼吸困难（P =.001）和疼痛（P =.003），在感官（P <.000）、社会接触（P =.002）和言语（P =.010）方面得分更高且困难更大。同步放化疗组报告口干（P <.000）和唾液黏稠（P =.005）问题更多。
我们发现接受同步放化疗的患者长期生活质量得分更高。这似乎主要是因为身体功能、社会功能和社会接触更好，以及在疼痛、呼吸、言语、感官和睡眠障碍方面的问题更小。
