Chamlin Sarah L, Haggstrom Anita N, Drolet Beth A, Baselga Eulalia, Frieden Ilona J, Garzon Maria C, Horii Kimberly A, Lucky Anne W, Metry Denise W, Newell Brandon, Nopper Amy Jo, Mancini Anthony J
Division of Pediatric Dermatology, Children's Memorial Hospital and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
J Pediatr. 2007 Dec;151(6):684-9, 689.e1. doi: 10.1016/j.jpeds.2007.04.055. Epub 2007 Aug 24.
To identify clinical features of infants with ulcerated infantile hemangiomas.
Cross-sectional analysis was conducted within a prospective cohort study of children with infantile hemangiomas. Children younger than 12 years of age were recruited. Demographic and prenatal/perinatal information was collected. Hemangioma size, location, subtype, course, complications, and treatments were recorded.
One thousand ninety-six patients were enrolled, and 173 (15.8%) patients experienced ulceration. Ulceration occurred in 192 (9.8%) of 1960 [corrected] total hemangiomas. Hemangiomas with ulcerations were more likely large, mixed clinical type, segmental morphologic type, and located on the lower lip, neck, or anogenital region. Ulceration occurred at a median age of 4 months, most often during the proliferative phase. Children with ulcerated hemangiomas were more likely to present to a pediatric dermatologist at a younger age and to require treatment. Bleeding occurred in 41% of ulcerated lesions but was rarely of clinical significance. Infection occurred in 16%.
Ulceration occurs in nearly 16% of patients with infantile hemangiomas, most often by 4 months of age, during the proliferative phase. Location, size, and clinical and morphologic type are associated with an increased risk for development of ulceration.
确定患有溃疡型婴儿血管瘤的婴儿的临床特征。
在一项针对婴儿血管瘤患儿的前瞻性队列研究中进行横断面分析。招募了12岁以下的儿童。收集了人口统计学和产前/围产期信息。记录了血管瘤的大小、位置、亚型、病程、并发症和治疗情况。
共纳入1096例患者，173例（15.8%）发生溃疡。在1960个[校正后]总血管瘤中，192个（9.8%）发生溃疡。发生溃疡的血管瘤更可能较大、为混合临床类型、节段性形态学类型，且位于下唇、颈部或肛门生殖器区域。溃疡发生的中位年龄为4个月，最常发生在增殖期。患有溃疡型血管瘤的儿童更可能在较年幼时就诊于儿科皮肤科医生且需要治疗。41%的溃疡病变发生出血，但很少具有临床意义。16%发生感染。
近16%的婴儿血管瘤患者发生溃疡，最常发生在4个月龄时的增殖期。位置、大小以及临床和形态学类型与溃疡形成风险增加相关。
