Neal D E, Kaack M B, Baskin G, Roberts J A
Department of Urology, Tulane Regional Primate Research Center, Covington, Louisiana 70433.
Antimicrob Agents Chemother. 1991 Nov;35(11):2340-4. doi: 10.1128/AAC.35.11.2340.
While acute pyelonephritis is known to elicit an antibody response, it is also known that a patient who has had pyelonephritis once is susceptible to recurrent renal infection. Using our experimental model of pyelonephritis in the monkey, we tested whether antibiotic therapy of the acute disease would affect the antibody response. We found that it did, because antibiotic therapy beginning 72 h after bacterial inoculation attenuated the antibody response so that rechallenge 3 months later produced acute pyelonephritis and prolonged bacteriuria. The animals with untreated infection had an antibody response that lasted a sufficient period of time to prevent acute pyelonephritis after renal challenge. We have confirmed that antibody titers against P fimbriae are protective, and to a degree, this protective effect may be abrogated by antibiotic therapy.
虽然已知急性肾盂肾炎会引发抗体反应，但也知道曾患过一次肾盂肾炎的患者易反复发生肾脏感染。利用我们在猴子身上建立的肾盂肾炎实验模型，我们测试了急性疾病的抗生素治疗是否会影响抗体反应。我们发现确实如此，因为在细菌接种后72小时开始的抗生素治疗减弱了抗体反应，以至于3个月后再次感染时会引发急性肾盂肾炎并导致细菌尿持续时间延长。未接受治疗的感染动物产生的抗体反应持续了足够长的时间，以防止肾脏再次感染后发生急性肾盂肾炎。我们已经证实，针对P菌毛的抗体滴度具有保护作用，并且在一定程度上，这种保护作用可能会被抗生素治疗所消除。
