Matsuo Toshihiko, Ichimura Kouichi, Yoshino Tadashi
Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
J Clin Exp Hematop. 2007 Nov;47(2):79-81. doi: 10.3960/jslrt.47.79.
We report the case of a patient who showed spontaneous regression of bilateral conjunctival extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). A 72-year-old man underwent excisional biopsy for salmon-pink lesions involving the whole circumference of the conjunctiva in the right eye and the lower fornix in the left eye. Histopathology and immunohistochemistry showed MALT lymphoma with immunoglobulin kappa monotype shared by the lesions in both eyes. Because the patient had recurrent pulmonary tuberculosis, radiation initially planned for the large residual lesion in the right eye was postponed. Over two years, including 6 mon with anti-tuberculous treatment, the large lesion in the right eye showed spontaneous regression. The spontaneous regression of conjunctival MALT lymphoma observed in this patient suggests that following excisional biopsy for histopathological diagnosis, observation is a treatment option.
我们报告了一例双侧结膜黏膜相关淋巴组织边缘区B细胞淋巴瘤（MALT淋巴瘤）出现自发消退的病例。一名72岁男性因右眼结膜全周及左眼下部穹窿部出现鲑鱼粉红色病变接受了切除活检。组织病理学和免疫组化显示为MALT淋巴瘤，双眼病变均为免疫球蛋白κ单型。由于该患者患有复发性肺结核，最初计划用于右眼大的残留病变的放疗被推迟。在包括6个月抗结核治疗在内的两年多时间里，右眼的大病变出现了自发消退。该患者中观察到的结膜MALT淋巴瘤自发消退提示，在进行切除活检以进行组织病理学诊断后，观察也是一种治疗选择。
