质粒pDGO100的In7整合子中一种新的甲氧苄啶抗性基因dhfrX。
A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100.
作者信息
Parsons Y, Hall R M, Stokes H W
机构信息
School of Biological Sciences, Macquarie University, Sydney, NSW, Australia.
出版信息
Antimicrob Agents Chemother. 1991 Nov;35(11):2436-9. doi: 10.1128/AAC.35.11.2436.
Abstract
A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.
摘要
在pDGO100的In7整合子中鉴定出一种新的甲氧苄啶抗性决定簇，命名为dhfrX。dhfrX二氢叶酸还原酶的序列与几种已知二氢叶酸还原酶蛋白的序列具有高达28%的同一性。dhfrX基因与In7整合子的第二个3'-保守区段相邻，但该区段的前77个碱基不存在。
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