AAD(2'')氨基糖苷腺苷酰基转移酶决定簇aadB的核苷酸序列。该区域与R538-1中aadA周围区域以及R388中dhfrII周围区域的进化关系。
Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388.
作者信息
Cameron F H, Groot Obbink D J, Ackerman V P, Hall R M
出版信息
Nucleic Acids Res. 1986 Nov 11;14(21):8625-35. doi: 10.1093/nar/14.21.8625.
Abstract
The nucleotide sequence of the aadB gene which confers resistance to kanamycin, gentamicin, and tobramycin has been determined. The size of the longest reading frame is 747 bases encoding a protein of predicted size 27,992 daltons. A segment of the aadB gene sequence (including the promoter region) was found upstream of the aadA gene in R538-1 and of the dhfrII gene in R388 and the proposed promoters for these genes coincide with the aadB promoter region. The sequence homology extends upstream to the end of the sequenced regions of R388 and R538-1. Almost perfect homology was also found between the sequences 3'- to the aadB gene and 3'- to the aadA genes of R538-1 and pSa. This segment includes a 59 base element previously found flanking the Tn7 aadA gene. A model is presented for the evolution of this region of the plasmid genomes in which the 59- base element functions as an insertional "hot spot" and the possibility that this region is analogous to the aadA/aadB region of the Tn21- like transposon family is considered.
摘要
已确定赋予卡那霉素、庆大霉素和妥布霉素抗性的aadB基因的核苷酸序列。最长读码框的大小为747个碱基，编码一个预测大小为27,992道尔顿的蛋白质。在R538 - 1中，aadB基因序列的一段（包括启动子区域）位于aadA基因上游，在R388中位于dhfrII基因上游，并且这些基因的推测启动子与aadB启动子区域一致。序列同源性向上游延伸至R388和R538 - 1测序区域的末端。在R538 - 1和pSa的aadB基因3'端与aadA基因3'端的序列之间也发现了几乎完全的同源性。该片段包括先前在Tn7 aadA基因侧翼发现的一个59碱基元件。提出了一个关于质粒基因组该区域进化的模型，其中59碱基元件作为一个插入“热点”发挥作用，并考虑了该区域类似于Tn21样转座子家族的aadA/aadB区域的可能性。
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