Denagamage Thomas N, O'Connor Annette M, Sargeant Jan M, Rajić Andrijana, McKean James D
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
Foodborne Pathog Dis. 2007 Winter;4(4):539-49. doi: 10.1089/fpd.2007.0013.
A systematic review was conducted to evaluate the efficacy of vaccination to reduce Salmonella prevalence in market weight finisher swine. A search of online databases and selected conference proceedings was conducted to identify relevant studies. The review process followed relevance screening, methodological quality assessment, and data extraction. Although multiple outcomes were frequently reported, only outcomes describing culture of Salmonella were extracted. Five clinical trials and 23 challenge studies were considered likely relevant to the review as they described vaccination to reduce Salmonella in swine. Five clinical trials reported vaccination was associated with reduced isolation of Salmonella in market weight pigs, however, information required to assess the internal validity of the study was often not described in the manuscripts. All challenge studies assessed vaccine efficacy in pigs aged <15 weeks reducing the relevance of results to the review which focused on market weight pigs. Only five of the 23 challenge studies reported the majority of information necessary to evaluate the quality of vaccine studies. Given large variability in population type, sample size, type of vaccine, dose and dosing regimens, and type of outcomes observed, pooled data analysis was not possible, and therefore, a qualitative synthesis of the studies was conducted. Available evidence suggests that vaccination is associated with reduced Salmonella prevalence in swine at or near harvest; however, this conclusion is based on studies with design and reporting deficiencies that could potentially indicate biases with the outcome.
开展了一项系统评价，以评估疫苗接种对降低上市体重育肥猪沙门氏菌感染率的效果。通过检索在线数据库和选定的会议论文集来识别相关研究。评价过程包括相关性筛选、方法学质量评估和数据提取。尽管经常报告多种结果，但仅提取了描述沙门氏菌培养的结果。五项临床试验和23项攻毒研究被认为可能与该评价相关，因为它们描述了用于降低猪沙门氏菌感染率的疫苗接种情况。五项临床试验报告称，疫苗接种与上市体重猪中沙门氏菌分离率降低有关，然而，稿件中往往未描述评估研究内部有效性所需的信息。所有攻毒研究均评估了15周龄以下仔猪的疫苗效力，这降低了研究结果与本评价的相关性，本评价重点关注上市体重猪。在23项攻毒研究中，只有五项报告了评估疫苗研究质量所需的大部分信息。鉴于在种群类型、样本量、疫苗类型、剂量和给药方案以及观察到的数据结果类型方面存在很大差异，无法进行汇总数据分析，因此，对这些研究进行了定性综合分析。现有证据表明，疫苗接种与出栏时或接近出栏时猪的沙门氏菌感染率降低有关；然而，这一结论是基于设计和报告存在缺陷的研究得出的，这些缺陷可能表明结果存在偏差。
