Oloya J, Theis M, Doetkott D, Dyer N, Gibbs P, Khaitsa M L
Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota.
Foodborne Pathog Dis. 2007 Winter;4(4):551-63. doi: 10.1089/fpd.2007.0014.
To evaluate the occurrence, serotypes, and antimicrobial susceptibility of Salmonellae from domestic animals and humans in North Dakota.
Salmonellosis data (2000-2005) in humans (n = 286) and animals (n = 258) were extracted from the North Dakota Department of Health (NDDoH) and North Dakota State University Veterinary Diagnostic Laboratory (NDSU-VDL), and analyzed for temporal and spatial trends, and for other associations. Additionally, random samples of 35, 30, and 15 Salmonella isolates from NDSU-VDL, NDDoH, and North Dakota healthy cattle, respectively, were tested for antimicrobial susceptibility.
Most animal salmonellosis occurred in cattle (64.7%) sheep (12%), pigs (10.9%), and bison (0.4%) with Salmonella Typhimurium (45.7%) as the predominant serotype; Salmonella Arizona (10.9%) and Dublin (10.5%) were host specific in sheep and cattle respectively. In humans, Salmonella Typhimurium (32.5%) and Salmonella Newport (11.2%) were predominant. Season influenced human (p = 0.027) and animal (p = 0.014) salmonellosis with cases peaking in the spring and summer for animals and humans, respectively. Salmonella Typhimurium case reports in humans were not seasonally related to domestic animals (p = 0.001) nor cattle (p = 0.001). Over time, case reports increased in humans but decreased in domestic animals. Most serotypes from domestic animals were multidrug resistant compared to human isolates. CONCLUSIONS AND APPLICATIONS: Many Salmonella serotypes (17) were involved in North Dakota human and animal salmonellosis with case reports closely related in fall and winter, but not during warmer months. Spatial clustering of human and animal cases was similar. Antimicrobial resistance was widespread but lower in human isolates. These data are helpful in determining future policy, research, and control strategies for salmonellosis in humans and domestic animals.
评估北达科他州家畜和人类沙门氏菌的发生情况、血清型及抗菌药物敏感性。
从北达科他州卫生部（NDDoH）和北达科他州立大学兽医诊断实验室（NDSU - VDL）提取2000 - 2005年人类（n = 286）和动物（n = 258）的沙门氏菌病数据，分析其时间和空间趋势以及其他关联。此外，分别对从NDSU - VDL、NDDoH和北达科他州健康牛中随机抽取的35株、30株和15株沙门氏菌分离株进行抗菌药物敏感性测试。
大多数动物沙门氏菌病发生在牛（64.7%）、绵羊（12%）、猪（10.9%）和野牛（0.4%）中，鼠伤寒沙门氏菌（45.7%）为主要血清型；亚利桑那沙门氏菌（10.9%）和都柏林沙门氏菌（10.5%）分别在绵羊和牛中具有宿主特异性。在人类中，鼠伤寒沙门氏菌（32.5%）和纽波特沙门氏菌（11.2%）为主要类型。季节对人类（p = 0.027）和动物（p = 0.014）沙门氏菌病有影响，动物病例在春季达到高峰，人类病例在夏季达到高峰。人类鼠伤寒沙门氏菌病例报告与家畜（p = 0.001）和牛（p = 0.001）均无季节性关联。随着时间推移，人类病例报告增加，而家畜病例报告减少。与人类分离株相比，家畜的大多数血清型对多种药物耐药。结论与应用：北达科他州人类和动物沙门氏菌病涉及多种血清型（17种），病例报告在秋季和冬季密切相关，但在温暖月份则不然。人类和动物病例的空间聚集情况相似。抗菌药物耐药性普遍存在，但在人类分离株中较低。这些数据有助于确定未来人类和家畜沙门氏菌病的政策、研究和控制策略。
