Inzitari Marco, Newman Anne B, Yaffe Kristine, Boudreau Robert, de Rekeneire Nathalie, Shorr Ronald, Harris Tamara B, Rosano Caterina
Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Neuroepidemiology. 2007;29(3-4):156-62. doi: 10.1159/000111577. Epub 2007 Nov 27.
BACKGROUND/AIMS: Gait speed is cross-sectionally associated with attention and psychomotor speed in older community dwellers. It is unclear if gait speed predicts decline in these cognitive domains over time.
Usual gait speed (m/s) over 6 m was measured at baseline in 2,776 Health, Aging and Body Composition Study participants (mean age +/- SD 73.5 +/- 2.8 years, 53% women, 37% blacks). The Digit Symbol Substitution Test (DSST) was administered at baseline and after 5 years to assess attention and psychomotor speed. We used multivariate logistic regression models to calculate the risk of DSST 5-year decline [>1 SD from mean change (9 points)] across quartiles of gait speed, adjusting for demographics, weight, physical activity, comorbidities, depression and Modified Mini-Mental State Examination.
After 5 years, 389 (17.1%) participants declined in DSST. Compared to those in the highest quartile of gait speed (>1.35 m/s), participants in the lowest quartile (<1.05 m/s) were more likely to decline in DSST independently of the considered covariates (OR 1.74, 95% CI 1.21-2.51, adjusted p for trend across quartiles = 0.006).
In this cohort of older community dwellers, gait speed independently predicted a decline in DSST after 5 years.
背景/目的：在老年社区居民中，步速与注意力和精神运动速度存在横断面关联。目前尚不清楚步速是否能预测这些认知领域随时间的衰退情况。
在2776名健康、衰老和身体成分研究参与者（平均年龄±标准差73.5±2.8岁，53%为女性，37%为黑人）的基线期测量其6米的常规步速（米/秒）。在基线期和5年后进行数字符号替换测验（DSST）以评估注意力和精神运动速度。我们使用多变量逻辑回归模型来计算步速四分位数范围内DSST 5年衰退[相对于平均变化>1个标准差（9分）]的风险，并对人口统计学、体重、身体活动、合并症、抑郁和改良简易精神状态检查进行了调整。
5年后，389名（17.1%）参与者的DSST出现衰退。与步速最高四分位数（>1.35米/秒）的参与者相比，步速最低四分位数（<1.05米/秒）的参与者在不考虑协变量的情况下，DSST更有可能出现衰退（比值比1.74，95%置信区间1.21 - 2.51，四分位数间趋势的校正p值 = 0.006）。
在这个老年社区居民队列中，步速独立预测了5年后DSST的衰退情况。
