Nickles R J, Avila-Rodriguez M A, Nye J A, Houser E N, Selwyn R G, Schueller M J, Christian B T, Jensen M
Medical Physics Department, University of Wisconsin, Madison, WI 53706, USA.
Q J Nucl Med Mol Imaging. 2008 Jun;52(2):134-9. Epub 2007 Nov 28.
Over a hundred proton-induced reactions have been studied at the University of Wisconsin Medical Physics department since the installation of the first CTI RDS 112 in 1985. The focus has been to measure thick target yields at 11 MeV, in an effort to concentrate on the practical production of positron emitting radionuclides that have favorable decay characteristics, high yields and the potential for labeling pivotal biological tracers. This review covers our recent advances to scale-up the production of the heavy halogens and transition metals as feed-stock for non-conventional PET tracers that are currently attracting increased attention in oncology.
自1985年安装第一台CTI RDS 112以来，威斯康星大学医学物理系已经研究了一百多种质子诱导反应。重点是测量11 MeV时的厚靶产额，致力于实际生产具有良好衰变特性、高产额以及标记关键生物示踪剂潜力的正电子发射放射性核素。本综述涵盖了我们近期在扩大重卤素和过渡金属生产规模方面取得的进展，这些物质作为非常规PET示踪剂的原料，目前在肿瘤学领域正受到越来越多的关注。
