Li G, Li M, Ma J, Zhao S
Institute of Oncology, CAMS, Beijing.
Chin Med Sci J. 1991 Jun;6(2):119-21.
N-2-methylpropyl-N-1-methylacetonyl-nitrosamine (NMAMPA), first isolated from moldy and normal foods, was synthesized by chemical means. The structure and molecular weight of the synthetic NMAMPA were elucidated by spectrometry. A combination of spectral and chromatographic data indicated that the synthetic NMAMPA is identical to that obtained naturally. Synthetic NMAMPA is a racemic modification, and a carcinogen which can induce esophageal and forestomach cancer in rats.
N-2-甲基丙基-N-1-甲基丙酮基亚硝胺（NMAMPA）最初是从发霉和正常食物中分离出来的，现已通过化学方法合成。合成的NMAMPA的结构和分子量通过光谱法得以阐明。光谱和色谱数据的结合表明，合成的NMAMPA与天然获得的NMAMPA相同。合成的NMAMPA是一种外消旋变体，是一种能在大鼠中诱发食管癌和前胃癌的致癌物。
