患有炎症性和肿瘤性肝病的犬类体内胰岛素样生长因子I的浓度

Insulin-like growth factor I concentration in dogs with inflammatory and neoplastic liver diseases.

作者信息

Neumann S, Welling H, Thuere S

机构信息

Institute of Veterinary Medicine, University of Goettingen, Burckhardtweg 2, D-37077 Goettingen, Germany.

出版信息

J Vet Med A Physiol Pathol Clin Med. 2007 Dec;54(10):612-7. doi: 10.1111/j.1439-0442.2007.00982.x.

DOI:10.1111/j.1439-0442.2007.00982.x

PMID:18045348

Abstract

Liver diseases are known to influence the serum concentration of insulin-like growth factor I (IGF-I) in humans, but such an effect has rarely been investigated in dogs. The aim of this study was to investigate serum IGF-I concentrations in dogs with primary liver diseases, in comparison with levels in healthy dogs and dogs with non-hepatic diseases. For this purpose, IGF-I serum concentrations were measured (DSL-5600 kit) in 36 dogs with various liver diseases and compared with 22 healthy controls and 20 dogs with non-hepatic diseases. The results showed that dogs with liver diseases had significantly lower IGF-I serum concentrations (P < 0.001) than clinical healthy dogs or dogs with non-hepatic diseases. But the results also indicate that the aetiology of liver disease has no influence on IGF-I serum concentration.

摘要

众所周知，肝脏疾病会影响人类血清中胰岛素样生长因子I（IGF-I）的浓度，但这种影响在犬类中鲜有研究。本研究旨在调查患有原发性肝脏疾病的犬类血清IGF-I浓度，并与健康犬和患有非肝脏疾病的犬类进行比较。为此，对36只患有各种肝脏疾病的犬类测量了IGF-I血清浓度（使用DSL-5600试剂盒），并与22只健康对照犬和20只患有非肝脏疾病的犬类进行比较。结果显示，患有肝脏疾病的犬类血清IGF-I浓度显著低于临床健康犬或患有非肝脏疾病的犬类（P < 0.001）。但结果也表明，肝脏疾病的病因对IGF-I血清浓度没有影响。