Northwest Surgeons, Delamere House, Ashville Point, Sutton Weaver, Cheshire WA7 3FW, UK.
Vet Rec. 2013 Dec 14;173(23):579. doi: 10.1136/vr.101306. Epub 2013 Oct 24.
Dogs with liver disease have been shown to have increased serum C-reactive protein (CRP) concentrations. However, it is unclear whether dogs with liver disease also have increased serum haptoglobin concentrations. The aim of the study was to measure serum haptoglobin concentrations in healthy dogs, hospitalised dogs and dogs with liver diseases. Haptoglobin concentrations were measured in 30 healthy dogs, 47 hospitalised dogs with non-hepatic illness, 46 dogs with congenital portosystemic shunt (cPSS) and 11 dogs with primary hepatopathy. Haptoglobin concentrations were not significantly different between cPSS dogs with and without hepatic encephalopathy (HE), thus all cPSS dogs were considered as one group. Haptoglobin concentrations were significantly different between the remaining groups (P<0.0001). Hospitalised ill dogs had significantly higher haptoglobin concentrations than healthy dogs (P<0.001), dogs with cPSS (P<0.001) and dogs with primary hepatopathy (P<0.05). There was no significant difference between haptoglobin concentrations in healthy dogs, dogs with cPSS and dogs with primary hepatopathy. Haptoglobin concentrations were not significantly increased in dogs with liver diseases or in dogs with cPSS and HE. This is in contrast with the previously reported CRP results. This study demonstrates that liver function should be considered when interpreting haptoglobin concentrations in dogs.
患有肝病的狗的血清 C 反应蛋白（CRP）浓度已被证明有所增加。然而，尚不清楚患有肝病的狗的血清结合珠蛋白浓度是否也会增加。本研究旨在测量健康犬、住院犬和肝病犬的血清结合珠蛋白浓度。在 30 只健康犬、47 只患有非肝脏疾病的住院犬、46 只先天性门体分流（cPSS）犬和 11 只原发性肝病犬中测量了结合珠蛋白浓度。患有和不患有肝性脑病（HE）的 cPSS 犬之间的结合珠蛋白浓度没有显著差异，因此所有 cPSS 犬都被视为一组。其余各组之间的结合珠蛋白浓度存在显著差异（P<0.0001）。患病住院的犬的结合珠蛋白浓度明显高于健康犬（P<0.001）、cPSS 犬（P<0.001）和原发性肝病犬（P<0.05）。健康犬、cPSS 犬和原发性肝病犬之间的结合珠蛋白浓度无显著差异。肝病犬或患有 cPSS 和 HE 的犬的结合珠蛋白浓度没有显著增加。这与之前报告的 CRP 结果形成对比。本研究表明，在解释犬的结合珠蛋白浓度时应考虑肝功能。
