Vet Rec. 2012 Jul 7;171(1):19. doi: 10.1136/vr.100627. Epub 2012 Jun 15.
Dogs with liver disorders often display gastrointestinal signs that may be triggered by ulceration. The liver is important for inactivation of some forms of gastrin. Therefore, hypergastrinaemia has been implicated in the pathogenesis of gastrointestinal ulcerations related to liver dysfunction. The aim of this study was to determine serum gastrin concentrations in dogs with liver disease. Fasted blood samples were collected from 15 dogs with newly diagnosed liver disease and 18 healthy dogs. Gastrin concentrations were significantly lower in dogs with congenital portosystemic shunt compared with healthy dogs (P=0.003). No significant difference (P=0.6) in gastrin concentration was revealed between dogs with hepatocellular disease and healthy dogs. Serum gastrin concentrations were not significantly associated with the occurrence of vomiting, anorexia, diarrhoea, or melaena in dogs with liver disorders. These findings did not provide support for the role of hypergastrinaemia in the development of gastrointestinal signs associated with liver disease in dogs. Decreased serum concentrations of gastrin in a dog with liver disease may suggest the presence of portosystemic shunt. Further investigation is warranted to determine the importance of hyopogastrinaemia in congenital postosystemic shunts in dogs and to evaluate potential alterations in serum gastrin concentrations in specific hepatocellular diseases.
患有肝脏疾病的犬常表现出胃肠道症状，这些症状可能由溃疡引起。肝脏在某些形式的胃泌素失活中起重要作用。因此，高胃泌素血症与与肝功能障碍相关的胃肠道溃疡的发病机制有关。本研究旨在确定患有肝病的犬的血清胃泌素浓度。从 15 只新诊断为肝脏疾病的犬和 18 只健康犬中采集空腹血样。与健康犬相比，先天性门腔分流犬的胃泌素浓度显著降低（P=0.003）。与健康犬相比，肝细胞疾病犬的胃泌素浓度无显著差异（P=0.6）。在患有肝脏疾病的犬中，胃泌素浓度与呕吐、厌食、腹泻或黑便的发生无显著相关性。这些发现并未支持高胃泌素血症在犬肝脏疾病相关胃肠道症状发展中的作用。患有肝脏疾病的犬血清胃泌素浓度降低可能提示存在门腔分流。需要进一步研究以确定低胃泌素血症在犬先天性门腔分流中的重要性，并评估特定肝细胞疾病中血清胃泌素浓度的潜在变化。
