Neumann Stephan, Welling Heike, Thuere Sibylle
Small Animal Clinic, Institute of Veterinary Medicine, University of Goettingen, Goettingen, Germany.
J Am Anim Hosp Assoc. 2007 Jul-Aug;43(4):193-200. doi: 10.5326/0430193.
Because essential amino acids are metabolized in the liver, liver diseases may impair their catabolism. In this study, serum L-phenylalanine concentrations in 28 dogs with liver diseases were compared with those of 28 healthy dogs and 13 dogs with nonhepatic diseases. Dogs with liver diseases had significantly increased L-phenylalanine serum concentrations compared to healthy dogs (P<0.001) and to those with nonhepatic diseases (P<0.01). There were no significant differences among the L-phenylalanine serum concentrations of dogs with different degrees of liver diseases. The sensitivity and specificity of L-phenylalanine to fasting bile acids were comparable.
由于必需氨基酸在肝脏中代谢，肝脏疾病可能会损害其分解代谢。在本研究中，将28只患有肝脏疾病的犬的血清L-苯丙氨酸浓度与28只健康犬以及13只患有非肝脏疾病的犬的血清L-苯丙氨酸浓度进行了比较。与健康犬相比（P<0.001）以及与患有非肝脏疾病的犬相比（P<0.01），患有肝脏疾病的犬的血清L-苯丙氨酸浓度显著升高。不同程度肝脏疾病的犬的血清L-苯丙氨酸浓度之间没有显著差异。L-苯丙氨酸对空腹胆汁酸的敏感性和特异性相当。
