de Lemos Mário L, Hamata Linda, Jennings Sarah, Leduc Tanya
Provincial Systemic Therapy Program, British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada.
J Oncol Pharm Pract. 2007 Dec;13(4):237-40. doi: 10.1177/1078155207080802.
Mercaptopurine is a purine analog used for acute lymphoblatic leukemia and chronic myelogenous leukemias. Since it is inactivated by xanthine oxidase (XO), concurrent intake of substances containing XO may potentially reduce bioavailability of mercaptopurine. Cow's milk is known to contain a high level of XO. In vitro and in vivo data suggest that concurrent intake of cow's milk may reduce the bioavailability of mercaptopurine. This interaction may be clinically significant. Therefore most patients should try to separate the timing of taking mercaptopurine and drinking milk.
巯嘌呤是一种嘌呤类似物，用于治疗急性淋巴细胞白血病和慢性粒细胞白血病。由于它会被黄嘌呤氧化酶（XO）灭活，同时摄入含有XO的物质可能会降低巯嘌呤的生物利用度。已知牛奶中含有高水平的XO。体外和体内数据表明，同时摄入牛奶可能会降低巯嘌呤的生物利用度。这种相互作用可能具有临床意义。因此，大多数患者应尽量分开服用巯嘌呤和饮用牛奶的时间。
