Rey E, Delaunay L, Pons G, Murat I, Richard M O, Saint-Maurice C, Olive G
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
Eur J Clin Pharmacol. 1991;41(4):355-7. doi: 10.1007/BF00314967.
Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (tmax 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration. The results are consistent with an estimated mean bioavailability of 55%.
12名1至5岁的儿童被随机分配，通过静脉注射（IV）或鼻内（IN）途径接受0.2mg/kg的咪达唑仑。鼻内给药后观察到吸收迅速起效（达峰时间12分钟）。两种给药途径后的半衰期相似（鼻内给药为2.2小时，静脉注射为2.4小时）。鼻内给药后的表观血浆清除率和分布容积约为静脉注射后的两倍。结果与估计的平均生物利用度55%一致。
