Cole W H
Anaesth Intensive Care. 1982 Feb;10(1):36-9. doi: 10.1177/0310057X8201000108.
Midazolam was given intravenously to 100 children over the age of 8 years to induce anaesthesia and a similar control group was anaesthetised with diazepam. The actions of midazolam in children were found to be similar to those of diazepam. Midazolam acted more quickly in children than has been reported in adults. The effects on the circulation and respiration, and the incidence of postoperative amnesia were similar in children to that which has been reported in adults. The incidence of postoperative vomiting after midazolam was 1% in the recovery room and 32% during the first two postoperative days. Laboratory investigations did not demonstrate any adverse effects. Midazolam has a considerable advantage over diazepam being water soluble and injectable safely without dilution. This clinical trial suggests that midazolam is a satisfactory induction agent for children.
对100名8岁以上儿童静脉注射咪达唑仑以诱导麻醉，并用地西泮对一个相似的对照组进行麻醉。发现咪达唑仑在儿童中的作用与地西泮相似。咪达唑仑在儿童中的起效比在成人中报道的更快。对循环和呼吸的影响以及术后遗忘的发生率在儿童中与在成人中报道的相似。咪达唑仑术后呕吐的发生率在恢复室为1%，术后前两天为32%。实验室检查未显示任何不良反应。咪达唑仑相比地西泮有相当大的优势，它是水溶性的，无需稀释即可安全注射。这项临床试验表明咪达唑仑是一种令人满意的儿童诱导麻醉剂。
