Badiee Zohreh, Kelishadi Roya
Division of Neonatology, Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran.
Pediatr Cardiol. 2008 May;29(3):574-9. doi: 10.1007/s00246-007-9149-0. Epub 2007 Nov 29.
Premature coronary artery disease (CAD) and its risk factors are highly prevalent in Iran. It is well documented that atherosclerosis starts in childhood and there is evidence that this association with adult levels may originate at birth, so assessment of serum lipid levels in neonates might be of importance. In this study we aimed to measure serum lipoprotein and apolipoprotein levels in a representative sample of Iranian newborns. Cord blood lipid profile, apolipoprotein A, apolipoprotein B, and lipoprotein a (LPa) were analyzed in 378 full-term, Iranian newborns. The mean values of total cholesterol (TC), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A, apolipoprotein B, and Lpa in girls were 81.4 +/- 28.3, 35.9 +/- 22.4, 31.1 +/- 9.9, 87.9 +/- 20.2, 34.2 +/- 18.2, and 21.0 +/- 2.8 mg/dL, respectively; these values in boys were 75.2 +/- 21.1, 32.1 +/- 16.3, 28.8 +/- 8.7, 84.3 +/- 16.0, 32.6 +/- 14.2, and 19.5 +/- 2.7 mg/dL, respectively. Median values of triglycerides (TGs) in boys and girls were 61 and 62 mg/dL, respectively. Female neonates had significantly higher concentrations of TC and HDL-C than males (81.4 +/- 28.3 vs. 75.2 +/- 21.1, p = 0.02, and 31.18 +/- 9.97 vs. 28.8 +/- 8.7, p = 0.02, respectively). Other biochemical factors were not significantly different between genders. The mean and median concentrations of LPa were 20.3 and 18.7 mg/dL, respectively, which are almost five times higher than those reported in some other studies. The TG concentration was 1.5-2 times higher than those previously reported. Our findings indicate that serum concentrations of LPa and TG in Iranian neonates are higher than those in previous studies; this disorder, which is likely placing Iranians at increased risk for future CADs, needs to be assessed in longitudinal studies.
早发性冠状动脉疾病（CAD）及其危险因素在伊朗极为普遍。有充分的文献记载，动脉粥样硬化始于儿童期，并且有证据表明这种与成人水平的关联可能始于出生时，因此评估新生儿的血脂水平可能具有重要意义。在本研究中，我们旨在测量伊朗新生儿代表性样本中的血清脂蛋白和载脂蛋白水平。对378名足月伊朗新生儿的脐带血脂谱、载脂蛋白A、载脂蛋白B和脂蛋白a（LPa）进行了分析。女孩的总胆固醇（TC）、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A、载脂蛋白B和Lpa的平均值分别为81.4±28.3、35.9±22.4、31.1±9.9、87.9±20.2、34.2±18.2和21.0±2.8mg/dL；男孩的这些值分别为75.2±21.1、32.1±16.3、28.8±8.7、84.3±16.0、32.6±14.2和19.5±2.7mg/dL）。男孩和女孩的甘油三酯（TGs）中位数分别为61和62mg/dL。女性新生儿的TC和HDL-C浓度显著高于男性（分别为81.4±28.,3与75.2±21.1，p = 0.02；31.18±9.97与28.8±8.7，p = ）。其他生化因素在性别之间没有显著差异。LPa的平均浓度和中位数浓度分别为20.3和18.7mg/dL），几乎比其他一些研究报告的高五倍。TG浓度比先前报告的高1.5至2倍。我们的研究结果表明，伊朗新生儿的LPa和TG血清浓度高于先前的研究；这种情况可能使伊朗人未来患CAD的风险增加，需要在纵向研究中进行评估。
