Liu Chao, He Chuan, Shi Wei, Chen Mao, Lei Aiwen
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
Org Lett. 2007 Dec 20;9(26):5601-4. doi: 10.1021/ol702456z. Epub 2007 Dec 4.
A simple yet powerful Ni catalyst can be used to promote direct arylations of alpha-halocarbonyl compounds, including a range of esters, amides, and ketones, with various arylboronic acids under mild conditions. The method tolerates beta-hydrogens and functional groups in the substrates and offers reactivity and selectivity profiles that are complementary to those found in the well-established Buchwald-Hartwig approach.
一种简单却强大的镍催化剂可用于在温和条件下促进α-卤代羰基化合物（包括一系列酯、酰胺和酮）与各种芳基硼酸的直接芳基化反应。该方法能耐受底物中的β-氢和官能团，并提供与成熟的布赫瓦尔德-哈特维希方法互补的反应活性和选择性特征。
