大鼠肝脏过氧化物酶体中的脂肪酰辅酶A氧化系统；降血脂药物氯贝丁酯对其的增强作用。
A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.
作者信息
Lazarow P B, De Duve C
出版信息
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2043-6. doi: 10.1073/pnas.73.6.2043.
Abstract
Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2 and NAD as electron acceptors. The system was detected by the ability of added palmitoyl-CoA to elicit O2 consumption, H2O2 production, and O2-dependent NAD reduction. The activity of this system is increased approximately one order of magnitude in rats treated with clofibrate, a hypolipidemic drug known to cause peroxisomal proliferation.
摘要
纯化的大鼠肝脏过氧化物酶体含有一种对氰化物不敏感的脂肪酰辅酶A氧化系统，该系统以氧气和NAD作为电子受体。通过添加棕榈酰辅酶A引发氧气消耗、过氧化氢生成以及依赖氧气的NAD还原的能力来检测该系统。在用氯贝丁酯（一种已知可导致过氧化物酶体增殖的降血脂药物）处理的大鼠中，该系统的活性增加了大约一个数量级。
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