Bedrick A E, Ramasamy G, Tchertkoff V
Department of Pathobiology and Oral Pathology, New York University College of Dentistry, NY 10010.
Am J Dermatopathol. 1991 Dec;13(6):575-8. doi: 10.1097/00000372-199113060-00008.
Histochemical determinations of copper, zinc, and iron in intradermal pigmented nevi and melanomas revealed the presence of copper and iron in melanoma but not in nevi. Zinc was not detected in either melanomas or nevi. However, melanin was removed from the tissues prior to staining; therefore, it is possible that zinc was also removed by the procedure. Although the function of copper and iron in the melanoma cell is not known, they may be components of abnormal enzymes.
对皮内色素痣和黑色素瘤进行铜、锌和铁的组织化学测定发现，黑色素瘤中存在铜和铁，而色素痣中没有。在黑色素瘤和色素痣中均未检测到锌。然而，在染色前黑色素已从组织中去除；因此，锌也有可能因该操作而被去除。虽然铜和铁在黑色素瘤细胞中的功能尚不清楚，但它们可能是异常酶的组成成分。
